L-glutamine import across plasma membrane

Across TCGA cell cohorts, RNA activity of the L-glutamine import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCF, ZNF814, and PTPRCAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, L-glutamine import across plasma membrane activity versus FANCF in BLOOD_Lymphoma (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FANCF →	+1.052	+0.226	<.001	<.001	3	3
BLOOD_Lymphoma	ZNF814 →	+1.756	+0.226	<.001	<.001	3	3
LARGE_INTESTINE	PTPRCAP →	-0.672	-0.203	.004	.006	3	3
LUNG_SCLC	SLC1A5 →	+2.008	+1.717	<.001	.003	3	3
LUNG_SCLC	TMEM132A →	-1.188	-1.090	.001	.006	3	3
LUNG_NSCLC_LUAD	PCSK4 →	-1.297	-0.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903803 vs FANCF — BLOOD_Lymphoma

Explore this scatter interactively →