Positive regulation of miRNA processing

Across TCGA patient cohorts, RNA activity of the Positive regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS8, EIF5AL1, and MYO9A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of miRNA processing activity versus ADAMTS8 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADAMTS8 →	-0.947	-0.301	<.001	.001	3	3
BRCA	EIF5AL1 →	+0.592	+0.597	.003	.001	3	3
BRCA	MYO9A →	-0.408	-0.643	.003	<.001	3	3
BRCA	MEF2C →	-0.467	-0.616	.002	<.001	3	3
OV	HSPBP1 →	+0.521	+0.423	<.001	.007	3	3
PDAC	THRB →	-0.372	-0.468	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903800 vs ADAMTS8 — LUAD

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