Positive regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD6, GDI1, and HSF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMAD6 grouped by Positive regulation of miRNA processing-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SMAD6 →	-1.239	-1.291	<.001	<.001	3	4
LUNG_SCLC	GDI1 →	+1.393	+1.194	.001	.005	3	3
CNS	HSF1 →	-0.310	-0.838	.005	.003	3	3
URINARY_TRACT	ACTA2 →	+2.346	+1.433	.003	.006	3	3
URINARY_TRACT	YAF2 →	+0.630	+1.449	.007	.005	3	3
URINARY_TRACT	ZNF17 →	+0.593	+1.984	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMAD6 by Positive regulation of miRNA processing activity — BONE

Explore this box plot interactively →