Positive regulation of miRNA processing

Across TCGA cell cohorts, RNA activity of the Positive regulation of miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRUB1, RCBTB1, and UROS, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of miRNA processing activity versus TRUB1 in LUNG_NSCLC_LUAD (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRUB1 →	+0.812	+0.360	.006	<.001	3	8
SKIN	RCBTB1 →	+0.711	+0.250	.001	.006	3	4
SKIN	UROS →	+0.578	+0.395	.005	.001	3	4
STOMACH	RAD54L2 →	+1.166	+0.579	<.001	.001	3	4
LARGE_INTESTINE	EDRF1 →	+1.351	+0.348	.002	.008	3	4
LUNG_NSCLC_LUAD	GSTO2 →	+3.293	+0.472	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903800 vs TRUB1 — LUNG_NSCLC_LUAD

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