Negative regulation of monoatomic anion transport

Across TCGA patient cohorts, RNA activity of the Negative regulation of monoatomic anion transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CPNE2, PPFIBP2_S387, and TMF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic anion transport activity versus CPNE2 in GBM (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CPNE2 →	+0.301	+0.087	.002	.005	3	5
LUAD	PPFIBP2_S387 →	+0.594	+0.074	<.001	.001	3	5
BRCA	TMF1 →	-0.285	-0.058	.001	.001	3	5
CCRCC	IL16_S795 →	-1.028	-0.085	<.001	<.001	3	5
GBM	APEH_S187 →	-0.316	-0.094	.006	.004	3	5
PDAC	ACSS2_S30 →	+0.460	+0.033	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903792 vs CPNE2 — GBM

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