Negative regulation of monoatomic anion transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of monoatomic anion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD69, CLCN6, and VSTM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD69 grouped by Negative regulation of monoatomic anion transport-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CD69 →	+0.256	+0.201	<.001	<.001	3	4
LIVER	CLCN6 →	-0.153	-0.221	.009	.003	3	4
UPPER_AERODIGESTIVE_TRACT	VSTM4 →	+0.145	+0.347	.004	<.001	3	4
LUNG_SCLC	CELF4 →	-0.167	-0.194	.005	.001	3	4
LUNG_NSCLC_LUSC	SPR →	-0.343	-0.186	.002	<.001	3	3
LUNG_NSCLC_LUSC	TAS2R7 →	-0.308	-0.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD69 by Negative regulation of monoatomic anion transport activity — LUNG_NSCLC_LUSC

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