Regulation of amino acid transmembrane transport

Across TCGA patient cohorts, RNA activity of the Regulation of amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCDH18, GDF6, and LRCH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amino acid transmembrane transport activity versus PCDH18 in CCRCC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PCDH18 →	-0.698	-0.381	.005	.002	3	5
CCRCC	GDF6 →	-0.957	-0.340	<.001	.005	3	4
UCEC	LRCH1 →	-0.432	-0.792	.005	.001	3	4
HNSC	ZNF25 →	-0.559	-0.250	.002	.007	3	4
GBM	RNU6-969P →	-0.652	-0.780	.001	<.001	3	4
CCRCC	RABGAP1 →	-0.441	-0.403	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903789 vs PCDH18 — CCRCC

Explore this scatter interactively →