Regulation of amino acid transmembrane transport

Across TCGA cell cohorts, RNA activity of the Regulation of amino acid transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, AFAP1L2, and RND3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of amino acid transmembrane transport activity versus ITGA3 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ITGA3 →	+2.467	+0.289	.006	.002	2	10
LIVER	AFAP1L2 →	+3.830	+0.421	<.001	<.001	3	7
LUNG_NSCLC_LUAD	RND3 →	+1.032	+0.184	.001	<.001	3	6
LUNG_NSCLC_LUAD	GPR1 →	+1.381	+0.178	.001	<.001	3	6
LIVER	ANXA8 →	+3.508	+0.312	.002	.005	3	6
BREAST	ARHGAP23 →	+2.703	+0.224	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903789 vs ITGA3 — LUNG_SCLC

Explore this scatter interactively →