Regulation of cardiac conduction

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac conduction pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, ANK2, and NEXN_S365, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac conduction activity versus CNRIP1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNRIP1 →	+0.580	+0.048	<.001	<.001	3	8
HNSC	ANK2 →	+0.522	+0.054	<.001	<.001	3	8
BRCA	NEXN_S365 →	+0.691	+0.029	<.001	<.001	3	8
HNSC	PDLIM3 →	+1.094	+0.067	<.001	<.001	3	8
LSCC	ARHGEF17_S546 →	+0.771	+0.081	<.001	<.001	3	8
COAD	PIP5K1C →	+0.380	+0.023	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903779 vs CNRIP1 — BRCA

Explore this scatter interactively →