Regulation of cardiac conduction

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNPY3, FXYD3, and WASHC2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac conduction activity versus CNPY3 in BLOOD_Leukemia (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNPY3 →	-1.159	-1.021	<.001	<.001	3	5
SKIN	FXYD3 →	+4.716	+0.867	<.001	.006	3	5
LUNG_NSCLC_LUAD	WASHC2C →	-0.514	-0.381	.003	.009	3	4
URINARY_TRACT	TRIM29 →	+6.420	+0.412	<.001	.005	3	4
URINARY_TRACT	CLDN7 →	+5.261	+0.319	<.001	.004	3	4
LUNG_SCLC	NTNG2 →	-1.760	-0.805	.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903779 vs CNPY3 — BLOOD_Leukemia

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