Regulation of potassium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Regulation of potassium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMT6, POLR3G, and E2F3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion export across plasma membrane activity versus TRMT6 in HNSC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRMT6 →	-0.561	-0.417	<.001	.004	3	4
LSCC	POLR3G →	-0.507	-0.334	.003	.009	3	4
GBM	E2F3 →	-0.388	-0.253	.005	.001	3	3
GBM	PRRC2C →	-0.267	-0.208	.006	.005	3	3
GBM	UTP14A →	-0.309	-0.255	.008	.004	3	3
GBM	MAML1 →	-0.311	-0.216	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903764 vs TRMT6 — HNSC

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