Regulation of potassium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ILKAP, STIP1, and NCAPD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ILKAP grouped by Regulation of potassium ion export across plasma membrane-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ILKAP →	+0.652	+1.056	.002	.002	3	5
SKIN	STIP1 →	+0.630	+0.826	.002	.009	1	6
OVARY	NCAPD2 →	+0.707	+0.796	<.001	.001	3	4
OVARY	GOT2 →	+1.061	+1.019	<.001	<.001	3	4
OVARY	INCENP →	+0.847	+0.874	.001	.006	3	4
OVARY	E2F4 →	+0.525	+0.766	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ILKAP by Regulation of potassium ion export across plasma membrane activity — OVARY

Explore this box plot interactively →