Regulation of potassium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Regulation of potassium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG1, PMCH, and BUB1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of potassium ion export across plasma membrane activity versus DLG1 in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	DLG1 →	+1.950	+1.536	<.001	.001	3	7
LUNG_NSCLC_LUAD	PMCH →	-0.083	-0.891	.003	.002	3	4
LIVER	BUB1B →	-1.270	-1.646	.003	<.001	3	4
BLOOD_Leukemia	IER2 →	-0.868	-0.349	.002	.004	3	4
OESOPHAGUS	GALK2 →	-0.620	-0.838	<.001	.008	3	3
URINARY_TRACT	MAPKBP1 →	-0.643	-1.358	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903764 vs DLG1 — OVARY

Explore this scatter interactively →