Negative regulation of p38MAPK cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of p38MAPK cascade pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLMH, EFNB3, and MSH6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of p38MAPK cascade activity versus BLMH in LSCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BLMH →	-1.055	-0.619	<.001	<.001	3	3
LSCC	EFNB3 →	-0.553	-0.470	<.001	<.001	3	3
LSCC	MSH6 →	-0.790	-0.600	<.001	<.001	3	3
GBM	MND1 →	-0.576	-0.311	<.001	<.001	3	3
LSCC	XPO5 →	-0.564	-0.474	.003	.004	3	3
LSCC	POLR2D →	-0.412	-0.538	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903753 vs BLMH — LSCC

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