Negative regulation of p38MAPK cascade

Across TCGA patient cohorts, RNA activity of the Negative regulation of p38MAPK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIK3_S915, EZR_S536, and SIN3B_S740, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of p38MAPK cascade activity versus SIK3_S915 in OV (Pearson r = 0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SIK3_S915 →	+0.623	+0.541	<.001	<.001	3	4
CCRCC	EZR_S536 →	+1.860	+0.785	<.001	<.001	2	5
GBM	SIN3B_S740 →	-0.434	-0.298	<.001	<.001	3	3
PDAC	MDC1_T1800 →	-0.606	-0.630	<.001	<.001	3	3
OV	RIN3_S875 →	+0.964	+0.799	<.001	<.001	3	3
OV	BAD_S25 →	+1.204	+0.980	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903753 vs SIK3_S915 — OV

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