Negative regulation of p38MAPK cascade

Across TCGA cell cohorts, RNA activity of the Negative regulation of p38MAPK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSP, ATP1A1, and COL17A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of p38MAPK cascade activity versus DSP in SKIN (Pearson r = 0.94).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DSP →	+4.797	+0.542	<.001	<.001	3	4
OESOPHAGUS	ATP1A1 →	+0.592	+0.172	.005	.007	3	4
OESOPHAGUS	COL17A1 →	+2.880	+0.219	.003	.008	3	3
BREAST	ESYT2 →	-1.269	-0.228	.001	.001	3	3
SKIN	CSNK1A1 →	+1.711	+0.542	<.001	<.001	3	3
SKIN	MYO1B →	+3.081	+0.542	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903753 vs DSP — SKIN

Explore this scatter interactively →