Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRAP1, DNAJA3, and MRPL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide activity versus TRAP1 in LSCC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TRAP1 →	+0.645	+0.074	<.001	<.001	3	8
OV	DNAJA3 →	+0.605	+0.050	<.001	<.001	3	7
BRCA	MRPL1 →	+0.380	+0.047	<.001	<.001	3	6
BRCA	PARN →	+0.395	+0.050	<.001	<.001	3	6
LSCC	PRMT3 →	+0.404	+0.082	<.001	<.001	3	6
LSCC	CYC1 →	+0.330	+0.048	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903750 vs TRAP1 — LSCC

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