Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide

Across TCGA cell cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9B, MEX3B, and MAP3K12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBC1D9B grouped by Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TBC1D9B →	-1.189	-0.298	<.001	<.001	2	6
BREAST	MEX3B →	-0.870	-0.538	.009	.009	3	4
LUNG_SCLC	MAP3K12 →	-1.443	-0.227	<.001	.006	2	5
UPPER_AERODIGESTIVE_TRACT	SNRPB2 →	-0.918	-0.223	.003	.004	3	4
BLOOD_Myeloma	MGAT4B →	-1.282	-0.343	.002	.006	2	5
UPPER_AERODIGESTIVE_TRACT	TSPAN5 →	-1.743	-0.265	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBC1D9B by Regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide activity — LUNG_SCLC

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