Positive regulation of establishment of protein localization to mitochondrion

Across TCGA patient cohorts, RNA activity of the Positive regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM133CP, FNDC3B, and HOPX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of establishment of protein localization to mitochondrion activity versus FAM133CP in LSCC (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM133CP →	+0.699	+0.096	.004	.005	3	4
PDAC	FNDC3B →	+0.349	+0.138	<.001	.001	3	3
LUAD	HOPX →	-1.325	-0.173	<.001	<.001	3	3
PDAC	ERGIC1 →	+0.312	+0.198	<.001	<.001	3	3
PDAC	VSTM2L →	+1.029	+0.142	.002	.002	3	3
PDAC	VOPP1 →	+0.165	+0.094	.008	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903749 vs FAM133CP — LSCC

Explore this scatter interactively →