Positive regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Positive regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPZ, ESD, and ATP2C2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPZ grouped by Positive regulation of establishment of protein localization to mitochondrion-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CPZ →	-4.156	-0.348	.001	.002	3	4
BLOOD_Leukemia	ESD →	+0.590	+0.202	.005	<.001	3	4
BREAST	ATP2C2 →	+1.978	+0.222	<.001	<.001	3	4
OESOPHAGUS	DEK →	-0.704	-0.244	.005	.002	3	4
OESOPHAGUS	HHLA3 →	-1.393	-0.448	<.001	<.001	3	4
STOMACH	MAP7D1 →	-0.983	-0.302	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPZ by Positive regulation of establishment of protein localization to mitochondrion activity — UPPER_AERODIGESTIVE_TRACT

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