Negative regulation of establishment of protein localization to mitochondrion

Across TCGA patient cohorts, RNA activity of the Negative regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02471, CAVIN1, and ZFP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of establishment of protein localization to mitochondrion activity versus LINC02471 in CCRCC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LINC02471 →	+1.072	+0.330	.003	.006	3	4
BRCA	CAVIN1 →	-0.714	-0.253	.006	.008	3	4
LSCC	ZFP1 →	-0.624	-0.418	<.001	.004	3	4
LSCC	DOK3 →	+0.658	+0.332	<.001	.001	3	3
UCEC	LINC00426 →	+0.668	+0.263	.005	.001	3	3
UCEC	RPS29P22 →	-0.744	-0.233	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903748 vs LINC02471 — CCRCC

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