Negative regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Negative regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO8, SRP54, and ATOX1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO8 grouped by Negative regulation of establishment of protein localization to mitochondrion-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FBXO8 →	-1.140	-2.097	.006	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SRP54 →	-0.892	-1.333	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ATOX1 →	-0.931	-1.300	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	COX19 →	-0.932	-1.929	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	PIGO →	-1.257	-1.850	.002	.001	3	3
UPPER_AERODIGESTIVE_TRACT	THOC3 →	-1.531	-1.825	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO8 by Negative regulation of establishment of protein localization to mitochondrion activity — BLOOD_Myeloma

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