Negative regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Negative regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VTA1, MSH6, and HMCES, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of establishment of protein localization to mitochondrion activity versus VTA1 in KIDNEY (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	VTA1 →	+0.561	+0.292	.004	.008	3	5
UPPER_AERODIGESTIVE_TRACT	MSH6 →	+1.139	+0.329	<.001	.002	3	5
SOFT_TISSUE	HMCES →	+1.081	+0.319	<.001	.001	3	4
SOFT_TISSUE	MRPL28 →	+0.636	+0.299	.008	.005	3	4
SKIN	BARD1 →	+0.647	+0.251	.002	.003	3	4
LUNG_NSCLC_LUAD	NME2 →	+0.510	+0.172	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903748 vs VTA1 — KIDNEY

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