Negative regulation of establishment of protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Negative regulation of establishment of protein localization to mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NAP1L1, RPSA, and CACYBP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of establishment of protein localization to mitochondrion activity versus NAP1L1 in LUNG_NSCLC_LUSC (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NAP1L1 →	+1.865	+0.423	.009	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	RPSA →	+1.765	+0.464	<.001	<.001	3	13
LUNG_NSCLC_LUSC	CACYBP →	+2.545	+0.459	<.001	.002	3	13
PANCREAS	BAG3 →	+1.532	+0.286	.003	.001	3	13
UPPER_AERODIGESTIVE_TRACT	STIP1 →	+1.501	+0.352	<.001	<.001	3	13
PANCREAS	DNAJA1 →	+1.599	+0.301	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903748 vs NAP1L1 — LUNG_NSCLC_LUSC

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