Regulation of plasma membrane organization

Across TCGA patient cohorts, RNA activity of the Regulation of plasma membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S854, DYNC1LI2_S194, and PRKG1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane organization activity versus SYNPO_S854 in CCRCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SYNPO_S854 →	+0.525	+0.038	<.001	<.001	3	6
LSCC	DYNC1LI2_S194 →	-0.506	-0.052	<.001	<.001	3	6
BRCA	PRKG1 →	+0.499	+0.055	<.001	<.001	3	6
LSCC	ARHGAP6 →	+0.332	+0.058	<.001	<.001	3	6
BRCA	RIN2_S486 →	+0.520	+0.060	<.001	<.001	3	5
GBM	SAAL1 →	-0.461	-0.060	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903729 vs SYNPO_S854 — CCRCC

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