Regulation of plasma membrane organization

Across TCGA patient cohorts, RNA activity of the Regulation of plasma membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK, COL8A1, and TIMP3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane organization activity versus AHNAK in BRCA (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AHNAK →	+0.963	+0.981	<.001	<.001	3	10
GBM	COL8A1 →	+1.914	+1.225	<.001	<.001	3	9
BRCA	TIMP3 →	+1.134	+0.809	<.001	<.001	3	8
BRCA	CYBRD1 →	+1.683	+0.850	<.001	<.001	3	8
LUAD	AXL →	+0.704	+0.966	<.001	<.001	3	8
UCEC	PLSCR4 →	+0.925	+0.814	.002	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903729 vs AHNAK — BRCA

Explore this scatter interactively →