Regulation of plasma membrane organization

Across TCGA cell cohorts, RNA activity of the Regulation of plasma membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA2, AHNAK, and S100A10, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of plasma membrane organization activity versus ANXA2 in BLOOD_Lymphoma (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ANXA2 →	+3.067	+0.251	<.001	<.001	3	13
BONE	AHNAK →	+2.188	+0.424	.001	<.001	3	10
LIVER	S100A10 →	+4.039	+0.490	.004	.006	2	10
BLOOD_Leukemia	LMNA →	+1.801	+0.186	.002	<.001	3	9
BONE	RHOC →	+2.412	+0.360	<.001	.001	3	8
BONE	THBS1 →	+5.534	+0.406	.003	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903729 vs ANXA2 — BLOOD_Lymphoma

Explore this scatter interactively →