Negative regulation of phospholipid metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of phospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPIN1, APOC1, and ABCA2, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phospholipid metabolic process activity versus LPIN1 in BONE (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LPIN1 →	+1.550	+0.177	.002	<.001	3	17
LIVER	APOC1 →	+3.714	+0.175	<.001	<.001	3	14
BLOOD_Leukemia	ABCA2 →	+2.265	+0.182	<.001	<.001	3	10
URINARY_TRACT	SLC66A3 →	+0.968	+0.146	.004	.004	1	9
BLOOD_Myeloma	LDHD →	+1.174	+0.295	.005	<.001	3	6
STOMACH	BCAT2 →	+0.997	+0.127	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903726 vs LPIN1 — BONE

Explore this scatter interactively →