Regulation of aerobic respiration

Across TCGA patient cohorts, RNA activity of the Regulation of aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DMGDH, TMEM150C, and BHMT2, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of aerobic respiration activity versus DMGDH in THYM (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	DMGDH →	+0.962	+0.026	<.001	<.001	3	19
THYM	TMEM150C →	+1.472	+0.036	<.001	<.001	3	19
THYM	BHMT2 →	+1.262	+0.023	<.001	<.001	2	19
CESC	PRKAA2 →	+0.885	+0.018	<.001	<.001	3	17
UVM	ATP7A →	+0.897	+0.034	<.001	<.001	3	17
UVM	TMEM135 →	+0.887	+0.025	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903715 vs DMGDH — THYM

Explore this scatter interactively →