Regulation of aerobic respiration

Across TCGA patient cohorts, RNA activity of the Regulation of aerobic respiration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRSF9, SF3B1, and SF3B3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of aerobic respiration activity versus SRSF9 in GBM (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SRSF9 →	-0.275	-0.031	<.001	<.001	3	5
GBM	SF3B1 →	-0.226	-0.038	<.001	.001	3	5
GBM	SF3B3 →	-0.167	-0.029	<.001	.001	3	5
OV	PDS5B →	-0.281	-0.042	<.001	<.001	3	5
GBM	ELP3 →	-0.155	-0.040	<.001	<.001	3	5
GBM	ANP32B_T15 →	-0.327	-0.028	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903715 vs SRSF9 — GBM

Explore this scatter interactively →