Regulation of aerobic respiration

Across TCGA cell cohorts, RNA activity of the Regulation of aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EBNA1BP2, NUP62, and EMC6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EBNA1BP2 grouped by Regulation of aerobic respiration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EBNA1BP2 →	+0.814	+0.204	<.001	.003	3	5
LUNG_SCLC	NUP62 →	-0.940	-0.172	<.001	.007	3	5
UPPER_AERODIGESTIVE_TRACT	EMC6 →	+0.778	+0.147	.005	.003	2	6
BLOOD_Lymphoma	HYKK →	+1.783	+0.363	<.001	<.001	3	4
BLOOD_Lymphoma	VARS1 →	+1.527	+0.435	.005	<.001	3	4
BREAST	ANK3 →	-1.645	-0.223	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EBNA1BP2 by Regulation of aerobic respiration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →