Regulation of aerobic respiration

Across TCGA cell cohorts, RNA activity of the Regulation of aerobic respiration pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF11, PTCH1, and NAT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of aerobic respiration activity versus ARHGEF11 in OVARY (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ARHGEF11 →	-0.748	-0.193	.002	<.001	3	6
OVARY	PTCH1 →	-2.076	-0.375	.002	<.001	3	6
URINARY_TRACT	NAT1 →	-1.278	-0.209	.002	.008	3	5
PANCREAS	LARP7 →	-0.594	-0.175	<.001	.001	3	5
SKIN	NDUFA4 →	-0.866	-0.211	<.001	<.001	3	5
BONE	SARNP →	-0.570	-0.273	.009	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903715 vs ARHGEF11 — OVARY

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