Positive regulation of hemopoiesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFXN4, MYH9, and RARA, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hemopoiesis activity versus SFXN4 in BONE (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SFXN4 →	-1.176	-0.074	<.001	.001	3	14
SOFT_TISSUE	MYH9 →	+1.517	+0.071	<.001	<.001	3	14
BLOOD_Lymphoma	RARA →	+1.067	+0.074	<.001	<.001	3	13
LARGE_INTESTINE	PLEKHM1 →	+1.360	+0.066	<.001	<.001	3	13
LARGE_INTESTINE	LASP1 →	+1.423	+0.073	<.001	<.001	3	13
BLOOD_Leukemia	ZFP36L1 →	+1.366	+0.043	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903708 vs SFXN4 — BONE

Explore this scatter interactively →