Positive regulation of hemopoiesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLU, YLPM1, and TIAM1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hemopoiesis activity versus CLU in STOMACH (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CLU →	-3.678	-0.305	.005	<.001	3	6
BLOOD_Leukemia	YLPM1 →	+0.577	+0.185	.003	.001	3	6
BLOOD_Myeloma	TIAM1 →	+3.347	+0.290	.006	<.001	1	8
BLOOD_Leukemia	SIPA1L1 →	+1.270	+0.170	.002	<.001	3	6
PANCREAS	KCNS3 →	+3.025	+0.272	.001	.001	3	6
KIDNEY	CEP128 →	+1.295	+0.410	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903708 vs CLU — STOMACH

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