Negative regulation of hemopoiesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCED1B-AS1, CIITA, and PIMREG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hemopoiesis activity versus PCED1B-AS1 in GBM (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCED1B-AS1 →	+0.566	+0.466	<.001	<.001	3	5
HNSC	CIITA →	+0.491	+0.369	.007	.004	3	5
GBM	PIMREG →	-0.981	-0.560	<.001	<.001	3	5
GBM	ADGRE4P →	+0.677	+0.411	<.001	<.001	3	5
UCEC	MIR222HG →	+0.929	+0.647	.001	<.001	3	5
UCEC	DAPP1 →	+0.857	+0.782	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903707 vs PCED1B-AS1 — GBM

Explore this scatter interactively →