Negative regulation of hemopoiesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, GCG, and EFR3A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MYOF grouped by Negative regulation of hemopoiesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYOF →	+1.848	+0.170	.001	.001	3	5
PANCREAS	GCG →	+0.163	+0.344	.002	<.001	3	4
BREAST	EFR3A →	+0.556	+0.106	.009	.005	3	4
SOFT_TISSUE	SLC35E4 →	+1.028	+0.215	.003	.008	3	4
BLOOD_Myeloma	MRPL10 →	+0.603	+0.257	.002	.004	3	4
KIDNEY	SPATA7 →	+0.761	+0.211	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MYOF by Negative regulation of hemopoiesis activity — BREAST

Explore this box plot interactively →