Negative regulation of hemopoiesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPCAM, CEP112, and PRXL2C, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hemopoiesis activity versus EPCAM in OVARY (Pearson r = -0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EPCAM →	-3.899	-0.402	<.001	<.001	3	8
URINARY_TRACT	CEP112 →	+1.301	+0.726	.002	.001	3	6
BLOOD_Lymphoma	PRXL2C →	+1.583	+0.225	.002	.004	3	6
OVARY	STARD8 →	+1.495	+0.503	<.001	<.001	3	6
LUNG_NSCLC_LUAD	KDF1 →	-2.483	-0.338	<.001	<.001	3	6
BLOOD_Lymphoma	NFIC →	+1.636	+0.249	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903707 vs EPCAM — OVARY

Explore this scatter interactively →