Positive regulation of DNA catabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of DNA catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL7L1, CRISPLD2, and NCL_S496, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA catabolic process activity versus RPL7L1 in CCRCC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RPL7L1 →	+0.144	+0.045	.006	.003	3	4
CCRCC	CRISPLD2 →	+0.532	+0.078	.003	.002	3	4
OV	NCL_S496 →	+0.923	+0.107	.006	<.001	3	4
LUAD	MNDA →	+0.794	+0.074	<.001	<.001	3	4
PDAC	DMXL1_S1896 →	-0.235	-0.042	<.001	.001	3	4
LSCC	STK24 →	-0.215	-0.066	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903626 vs RPL7L1 — CCRCC

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