Positive regulation of DNA catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC8D, EAF1, and PNN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRC8D grouped by Positive regulation of DNA catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC8D →	+0.571	+1.034	<.001	.002	3	4
BLOOD_Lymphoma	EAF1 →	+0.544	+1.691	.002	<.001	3	4
LIVER	PNN →	+0.988	+1.786	.002	<.001	3	3
LIVER	NEK11 →	-1.503	-1.504	<.001	.006	2	4
LIVER	RNF19B →	-0.761	-1.348	.003	.001	3	3
LIVER	ANKRD17 →	+0.844	+1.596	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRC8D by Positive regulation of DNA catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →