Positive regulation of DNA catabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of DNA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP3, FRY, and STK11IP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of DNA catabolic process activity versus CASP3 in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CASP3 →	+0.916	+0.244	.008	.001	2	5
BLOOD_Lymphoma	FRY →	-1.552	-0.231	.003	<.001	3	4
CNS	STK11IP →	-0.856	-0.872	<.001	.002	3	4
LARGE_INTESTINE	EPS8L1 →	-1.304	-0.643	.003	.003	3	4
SKIN	ABCF2 →	+0.642	+0.465	.003	.007	3	4
LUNG_SCLC	DCK →	+0.900	+0.213	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903626 vs CASP3 — BLOOD_Lymphoma

Explore this scatter interactively →