Protein localization to cytoplasmic stress granule

Across TCGA patient cohorts, RNA activity of the Protein localization to cytoplasmic stress granule pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are INPP4A, KIAA1143, and FAM83H_S870, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoplasmic stress granule activity versus INPP4A in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	INPP4A →	+0.273	+0.044	.001	<.001	3	7
PDAC	KIAA1143 →	+0.228	+0.024	<.001	<.001	3	6
LSCC	FAM83H_S870 →	-0.872	-0.035	<.001	<.001	3	6
HNSC	TBC1D5 →	+0.203	+0.074	<.001	<.001	2	6
HNSC	TOP2B →	+0.315	+0.060	.001	.001	2	6
CCRCC	CNRIP1 →	+0.434	+0.045	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903608 vs INPP4A — LSCC

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