Protein localization to cytoplasmic stress granule

Across TCGA patient cohorts, RNA activity of the Protein localization to cytoplasmic stress granule pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPTN, SERINC1, and ANXA11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoplasmic stress granule activity versus OPTN in GBM (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	OPTN →	-0.369	-0.072	.005	<.001	3	3
UCEC	SERINC1 →	-0.382	-0.138	.003	<.001	3	3
UCEC	ANXA11 →	-0.341	-0.091	.008	.003	3	3
UCEC	FBLN2 →	-0.979	-0.103	.002	.005	2	4
UCEC	PHYHIP →	-0.735	-0.160	.002	<.001	3	3
OV	CAVIN1 →	-0.981	-0.153	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903608 vs OPTN — GBM

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