Protein localization to cytoplasmic stress granule

Across TCGA cell cohorts, RNA activity of the Protein localization to cytoplasmic stress granule pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNL4B, KATNAL1, and ZC3HAV1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXNL4B grouped by Protein localization to cytoplasmic stress granule-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TXNL4B →	+0.624	+0.243	<.001	.005	3	4
CNS	KATNAL1 →	+0.880	+0.323	<.001	<.001	3	3
BLOOD_Lymphoma	ZC3HAV1 →	+1.364	+0.418	<.001	<.001	3	3
CNS	H2BC11 →	+1.203	+0.253	.004	.007	2	4
CNS	GREB1L →	-0.768	-0.184	.007	.007	3	3
URINARY_TRACT	HNRNPLL →	+0.463	+0.272	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXNL4B by Protein localization to cytoplasmic stress granule activity — LUNG_SCLC

Explore this box plot interactively →