Protein localization to cytoplasmic stress granule

Across TCGA cell cohorts, RNA activity of the Protein localization to cytoplasmic stress granule pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKRA, PRKAR1B, and NUSAP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoplasmic stress granule activity versus PRKRA in LARGE_INTESTINE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRKRA →	+0.457	+0.127	<.001	<.001	3	7
SOFT_TISSUE	PRKAR1B →	+1.714	+0.252	.007	.003	3	6
KIDNEY	NUSAP1 →	+1.543	+0.195	.009	.002	3	6
KIDNEY	KIF15 →	+1.291	+0.215	.003	.003	3	6
LUNG_SCLC	FAM117B →	+0.967	+0.127	.001	.004	3	6
BONE	USP45 →	+0.699	+0.175	.009	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903608 vs PRKRA — LARGE_INTESTINE

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