Positive regulation of autophagy of mitochondrion

Across TCGA patient cohorts, RNA activity of the Positive regulation of autophagy of mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAR1A, ASAP1, and SEC14L1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of autophagy of mitochondrion activity versus HAR1A in GBM (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HAR1A →	+0.379	+0.303	<.001	.002	3	3
CCRCC	ASAP1 →	-0.276	-0.524	.006	.002	3	3
LUAD	SEC14L1 →	-0.398	-0.156	<.001	<.001	3	3
LUAD	LDHD →	+0.772	+0.217	.001	.003	3	3
LSCC	MYL2 →	+0.093	+0.532	.001	<.001	3	2
LSCC	ZNF215 →	+0.525	+0.472	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903599 vs HAR1A — GBM

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