Positive regulation of gap junction assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of gap junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCO3, SAMD9, and GBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMCO3 grouped by Positive regulation of gap junction assembly-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMCO3 →	-1.269	-2.036	.002	.001	3	6
LIVER	SAMD9 →	-1.356	-1.154	.001	.005	3	5
OVARY	GBP3 →	-1.778	-1.012	<.001	<.001	3	4
LIVER	KLF10 →	-1.473	-1.715	.006	.002	3	4
KIDNEY	TGFA →	-2.617	-1.530	.002	<.001	3	4
KIDNEY	FAT4 →	-1.281	-1.202	.007	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMCO3 by Positive regulation of gap junction assembly activity — URINARY_TRACT

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