Positive regulation of gap junction assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of gap junction assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXTL2, DGKQ, and CEBPA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXTL2 grouped by Positive regulation of gap junction assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EXTL2 →	-0.234	-1.558	.003	.001	3	6
SKIN	DGKQ →	-0.206	-0.221	.004	.006	3	5
BLOOD_Leukemia	CEBPA →	+0.373	+1.302	<.001	<.001	3	4
SOFT_TISSUE	EPB41L4A →	-0.166	-1.211	.001	.002	3	4
SKIN	RAPGEF6 →	+0.290	+0.278	<.001	<.001	3	4
PANCREAS	USP32P2 →	+0.178	+0.398	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXTL2 by Positive regulation of gap junction assembly activity — BLOOD_Leukemia

Explore this box plot interactively →