Regulation of gap junction assembly

Across TCGA cell cohorts, RNA activity of the Regulation of gap junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEX3A, CHMP3, and SGMS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEX3A grouped by Regulation of gap junction assembly-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MEX3A →	+2.976	+1.988	.007	<.001	3	5
LIVER	CHMP3 →	-0.725	-1.312	.001	.003	3	5
LIVER	SGMS2 →	-2.265	-1.465	.001	.003	3	4
LUNG_NSCLC_LUAD	CHMP5 →	-0.487	-0.633	.001	.004	3	4
LUNG_NSCLC_LUSC	PTK2B →	+1.674	+1.295	.003	.006	3	4
LIVER	PNMA1 →	-1.518	-1.414	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEX3A by Regulation of gap junction assembly activity — BONE

Explore this box plot interactively →