Regulation of histamine secretion by mast cell

Across TCGA patient cohorts, RNA activity of the Regulation of histamine secretion by mast cell pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM, TFRC_S34, and RPLP0, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of histamine secretion by mast cell activity versus PALM in BRCA (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALM →	+0.593	+0.040	<.001	<.001	3	6
LSCC	TFRC_S34 →	-0.958	-0.050	<.001	<.001	3	6
GBM	RPLP0 →	-0.259	-0.092	<.001	<.001	3	5
GBM	TTC7B →	+0.274	+0.064	.001	.001	3	5
COAD	CAB39L →	+0.586	+0.042	<.001	.001	3	5
COAD	CFL2 →	+0.498	+0.039	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903593 vs PALM — BRCA

Explore this scatter interactively →