Regulation of histamine secretion by mast cell

Across TCGA patient cohorts, RNA activity of the Regulation of histamine secretion by mast cell pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF7, RGCC, and RAB5B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of histamine secretion by mast cell activity versus ARHGEF7 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGEF7 →	+0.615	+0.226	<.001	<.001	3	3
CCRCC	RGCC →	+0.901	+0.178	<.001	.001	3	3
COAD	RAB5B →	-0.287	-0.111	.003	.004	3	3
CCRCC	MAP3K6 →	+0.449	+0.162	.009	.002	3	3
CCRCC	FBXO22 →	-0.207	-0.134	.004	.001	3	3
CCRCC	OR7D4 →	-0.033	-0.211	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903593 vs ARHGEF7 — BRCA

Explore this scatter interactively →